CCT 018159
¥0
- 货号
- 282352619788846
- CAS 号
- [171009-07-7]
- 分子式
- C 20 H 20 N 2 O 4
- 分子量
- 352.39
- 规格
- 10mg; 50mg
- 规格(数值)
- 10 mg
- 别名
- 4-[4-(2,3-Dihydro-1,4-benzodioxin-6 -yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzene diol
- 溶解性
- Soluble to 5 mM in water and to 100 mM in DMSO
- 储存条件
- Store at +4°C
- 销量
- 0
产品描述
Novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity (IC 50 = 5.7 μM) that displays selectivity over human Hsp72 and topoisomerase II. Inhibits proliferation of HCT116 human colon tumor cells and produces upregulation of Hsp70 and downregulation of c-Raf and cdk4. More soluble than 17-AAG (Cat. No. 1515) and is independent of NQO1/DT-diaphorase and P-glycoprotein expression. Purity: >98 %