GW 3965 hydrochloride
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- 货号
- 2474
- CAS 号
- 405911-09-3
- 分子式
- C 33 H 31 NO 3 ClF 3 .HCl
- 分子量
- 618.51
- 规格
- 1mg; 10mg
- 规格(数值)
- 1 mg
- 别名
- 3-[3-[[[2-Chloro-3-(trifluoromethyl )phenyl]methyl](2,2-diphenylethyl)amino]propoxy]be nzeneacetic acid hydrochloride
- 溶解性
- Soluble to 100 mM in DMSO and to 20 mM in ethanol
- 应用说明
- HPLC>98 %
- 储存条件
- Desiccate at RT
- 销量
- 0
产品描述
Selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXRα and hLXRβ (EC 50 values are 190 and 30 nM respectively). Reduces angiotensin II-mediated increases in blood pressure; up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.