PSB 10 hydrochloride
¥0
- 货号
- PSB 10 hydrochloride
- CAS 号
- [591771-91-4]
- 分子式
- C 16 H 14 Cl 3 N 5 O.HCl
- 分子量
- 435.14
- 规格
- 10mg; 50mg
- 规格(数值)
- 10 mg
- 别名
- 8-Ethyl-1,4,7,8-tetrahydro-4-methyl -2-(2,3,5-trichlorophenyl)-5H-imidazo[2,1-i]purin- 5-one monohydrochloride
- 溶解性
- Soluble to 25 mM in DMSO and to 10 mM in ethanol
- 储存条件
- Desiccate at +4°C
- 销量
- 0
产品描述
Potent and highly selective antagonist for the human adenosine A 3 receptor, with low affinity for the rat A 3 receptor (K i values are 0.44 and > 17000 nM respectively). Displays > 3800-fold selectivity over human A 1 , A 2A and A 2B receptors (K i values are 4.1, 3.3 and 30 μM respectively) and > 1800-fold selectivity over rat A 1 and A 2A receptors. Acts as an inverse agonist in the [35S]GTPγS binding assay in hA 3 -CHO cells (IC 50 = 4 nM). Produces thermal hyperalgesia in mice in vivo. Purity: >98 %