T7056 Troglitazone 97322-87-7

产品描述

Troglitazone is a thiazolidinedione PPARγ agonist that exhibits anti-diabetic, anticancer, anti-fibrotic, and anti-inflammatory activities. Troglitazone contains a vitamin E-like ring structure that forms hepatotoxic metabolites in vivo. Troglitazone induces apoptosis in cervical cancer cells and decreases expression and activity of telomerase in ER- breast cancer cells. In vitro, troglitazone activates AMPK, decreases membrane potential, inhibits high glucose-closed ATP-sensitive K+ channels, and decreases insulin hypersecretion. In alveolar epithelial cells, troglitazone inhibits TGF-β1-induced activation of Akt, GSK-3β and Smad2/3, decreases β-catenin signaling, and suppresses epithelial-to-mesenchymal transition (EMT). Additionally, this compound inhibits PAM-induced increases in TGF-β1 and increases MUC1 expression in airway epithelial cells. References Chen HM, Zhang DG, Wu JX, et al. Ubiquitination of p53 is involved in troglitazone induced apoptosis in cervical cancer cells. Asian Pac J Cancer Prev. 2014;15(5):2313-8. PMID: 24716976. Deng R, Nie A, Jian F, et al. Acute exposure of beta-cells to troglitazone decreases insulin hypersecretion via activating AMPK. Biochim Biophys Acta. 2014 Jan;1840(1):577-85. PMID: 24144566. Zhou B, Buckley ST, Patel V, et al. Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism. PLoS One. 2012;7(6):e38827. PMID: 22745681. Park YS, Lillehoj EP, Kato K, et al. PPARγ inhibits airway epithelial cell inflammatory response through a MUC1-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1;302(7):L679-87. PMID: 22268120. Rashid-Kolvear F, Taboski MA, Nguyen J, et al. Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. BMC Cancer. 2010 Jul 22;10:390. PMID: 20650001. Ozaki S, Minamisono T, Yamashita T, et al. Supersaturation-nucleation behavior of poorly soluble drugs and its impact on the oral absorption of drugs in thermodynamically high-energy forms. J Pharm Sci. 2012 Jan;101(1):214-222. PMID: 21918988. 上海惠诚生物科技有限公司自2010年成立以来，一直致力于为客户提供试剂，仪器设备和耗材一站式服务。目前在苏州和南通的研发生产基地，专注于体外诊断蛋白，靶标蛋白，工业用酶和细胞因子的生产和定制，按照GMP标准，为工业客户提供大包装蛋白原料。 更多产品请联系惠诚生物！ 蛋白原料网站：www.acediag.com 全国统一服务热线：021- 60496554 24小时手机服务: 13917250134（同微信）QQ：1715451510 Email：info@e-biochem.com