XMD 8-92
¥0
- 货号
- XMD 8-92
- CAS 号
- [1234480-50-2]
- 分子式
- C 26 H 30 N 6 O 3
- 分子量
- 474.55
- 规格
- 10mg; 50mg
- 规格(数值)
- 10 mg
- 别名
- 2-[[2-Ethoxy-4-(4-hydroxy-1-piperid inyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-p yrimido[4,5-b][1,4]benzodiazepin-6-one
- 溶解性
- Soluble to 40 mM in DMSO
- 储存条件
- Store at RT
- 销量
- 0
产品描述
Highly selective ERK5/BMK1 inhibitor (K D values are 80, 190, 600 and 890 nM for BMK1, DCAMKL2, PLK4 and TNK1 respectively). Displays selectivity over 402 diverse kinases. Blocks growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. Also reduces BMK1-dependent transactivating activity of MEF2C. Inhibits proliferation in a variety of cancer cell lines; blocks tumor cell proliferation and tumor-associated angiogenesis. Purity: >98 %