YM 298198 hydrochloride
¥0
- 货号
- YM 298198 hydrochloride
- CAS 号
- [748758-45-4]
- 分子式
- C 18 H 22 N 4 OS.HCl
- 分子量
- 378.92
- 规格
- 10mg; 50mg
- 规格(数值)
- 10 mg
- 别名
- 6-Amino-N-cyclohexyl-N,3-dimethylth iazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
- 溶解性
- Soluble to 100 mM in water
- 储存条件
- Desiccate at +4°C
- 销量
- 0
产品描述
Non-competitive antagonist with high affinity and selectivity for mGlu 1 receptors (K i = 19 nM); inactive at other mGlu receptor subtypes (mGlu 2-7 ), ionotropic receptors and glutamate transporters (IC 50 > 10 μM). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC 50 values are 16 nM and 6.3 μM respectively), and is orally active in vivo, demonstrating an antinociceptive effect in hyperalgesic mice. Purity: >99 %