F5868 富马酸福莫特罗 Formoterol fumarate dihydrate 43229-80-7

产品描述

Formoterol is a long-acting β2-adrenergic receptor agonist that is clinically used to treat asthma and chronic obstructive pulmonary disease (COPD). Formoterol exhibits bronchodilatory, anti-asthma, and anti-obesity activities. In a clinical setting, formoterol increases resting energy expenditure, fat utilization, and mitochondrial biogenesis; it also increases mitochondrial expression of NADH dehydrogenase and ATP synthase. Lee P, Day RO, Greenfield JR, et al. Formoterol, a highly β2-selective agonist, increases energy expenditure and fat utilisation in men. Int J Obes (Lond). 2013 Apr;37(4):593-7. PMID: 22641064. Wills LP, Trager RE, Beeson GC, et al. The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis. J Pharmacol Exp Ther. 2012 Jul;342(1):106-18. PMID: 22490378. Rider CF, King EM, Holden NS, et al. Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. J Pharmacol Exp Ther. 2011 Sep;338(3):860-9. PMID: 21622733.