A6132 组蛋白脱乙酰酶抑制剂Apicidin 183506-66-3
- 货号
- A6132
- CAS 号
- [183506-66-3]
- 分子式
- C34H49N5O6
- 分子量
- 623.78
- 规格
- 1mg; 10mg
- 规格(数值)
- 1 mg
- 别名
- methyl 6-[(3S,6S,9S,12R)-3-butan-2-yl-6-[(1-methoxyindol-3-yl)methyl]-2,5,8, 11-tetraoxo-1,4,7,10-tetrazabicyclo[10.4.0]hexadecan-9-yl]hexanoate InChI: InChI=1S/C33H47N5O7/c1-5-21(2)29-33(43)37-18-12-11-16-27(37)32(42)34-24 (14-7-6-8-17-28(39)44-3)30(40)35-25(31(41)36-29)19-22-20-38(45-4)26-15- 10-9-13-23(22)26/h9-10,13,15,20-21,24-25,27,29H,5-8,11-12,14,16-19H2, 1-4H3,(H,34,42)(H,35,40)(H,36,41)/t21?,24-,25-,27+,29-/m0/s1
- 外观
- White Crystal Powder
- 溶解性
- Ethano (0.9 mg/mL)l, DMSO (0.9 mg/mL), Dichloromethane. Slightly soluble in water, methanol
- 应用说明
- ≥98%
- 熔点
- 190°C
- 储存条件
- 4°C
- 销量
- 0
产品描述
Description Apicidin is a cyclic tetrapeptide that inhibits histone deacetylase (HDAC) and exhibits anticancer benefit. In oral squamous cell carcinoma cells, apicidin upregulates expression of p21, inducing G2/M phase cell cycle arrest, apoptosis, and autophagy. In non-small cell lung cancer (NSCLC) cells, apicidin downregulates expression of checkpoint kinase (CHK) 1, decreases phosphorylation of cdc25C and cdc2, and upregulates expression of cdc25A, inducing apoptotic cell death. Additionally, apicidin increases apoptosis in Brc-Abl positive leukemia cells through disruption of the mitochondrial membrane potential, activation of caspases 3, 8, and 9, cleavage of poly(ADP)-ribose polymerase (PARP), and release of cytochrome c. Apicidin also induces apoptosis in eosinophils and neutrophils.