L2540 LGK-974 1243244-14-5
- 货号
- L2540
- CAS 号
- 1243244-14-5
- 分子式
- C23H20N6O
- 分子量
- 396.44
- 规格
- 1mg; 5mg
- 规格(数值)
- 1 mg
- 别名
- LGK974
- 外观
- White to off white powder
- 溶解性
- DMSO 79 mg/mL warmed (199.27 mM) Water Insoluble Ethanol Insoluble
- 应用说明
- ≥98%
- 储存条件
- -20°C
- 销量
- 0
产品描述
LGK-974 inhibits PORCN, suppressing Wnt signaling. This compound exhibits anticancer chemotherapeutic activity and is currently in clinical trials. LGK-974 inhibits proliferation and induces differentiation of pancreatic adenocarcinoma xenografts; it also shows efficacy in suppressing tumor growth in animal models of breast cancer and squamous cell carcinoma. References Liu J, Pan S, Hsieh MH, et al. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9. PMID: 24277854. Jiang X, Hao HX, Growney JD, et al. Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12649-54. PMID: 23847203. Jang J, Song J, Lee H, et al. LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/beta-catenin and NF-kB pathways. Exp Mol Med. 2021 Mar;53(3):407-421. PMID: 33692475. 上海惠诚生物科技有限公司自2010年成立以来，一直致力于为客户提供试剂，仪器设备和耗材一站式服务。目前在苏州和南通的研发生产基地，专注于体外诊断蛋白，靶标蛋白，工业用酶和细胞因子的生产和定制，按照GMP标准，为工业客户提供大包装蛋白原料。 更多产品请联系惠诚生物！ 蛋白原料网站：www.acediag.com 全国统一服务热线：021- 60496554 24小时手机服务: 13917250134（同微信）QQ：1715451510 Email：info@e-biochem.com