J8800 JW55 664993-53-7
- 货号
- J8800
- CAS 号
- 664993-53-7
- 分子式
- C25H26N2O5
- 分子量
- 434.49
- 规格
- 1mg; 5mg
- 规格(数值)
- 1 mg
- 别名
- Tankyrase 1/2 Inhibitor IV
- 溶解性
- 10 mM in DMSO
- 应用说明
- ≥98%
- 规格分类
- Xanthophylls
- 储存条件
- -20C
- 销量
- 0
产品描述
JW55 is an inhibitor of tankyrases (TNKS1/2) that stabilizes the β-catenin degradation complex, suppressing Wnt signaling. JW55 displays anti-obesity and potential anticancer activities. In animal models of high-fat diet and diabetes, JW55 decreases body weight and intestinal epithelial stem cell proliferation. References Mao J, Hu X, Xiao Y, et al. Overnutrition stimulates intestinal epithelium proliferation through β-catenin signaling in obese mice. Diabetes. 2013 Nov;62(11):3736-46. PMID: 23884889. Waaler J, Machon O, Tumova L, et al. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 2012 Jun 1;72(11):2822-32. PMID: 22440753. 上海惠诚生物科技有限公司自2010年成立以来，一直致力于为客户提供试剂，仪器设备和耗材一站式服务。目前在苏州和南通的研发生产基地，专注于体外诊断蛋白，靶标蛋白，工业用酶和细胞因子的生产和定制，按照GMP标准，为工业客户提供大包装蛋白原料。 更多产品请联系惠诚生物！ 蛋白原料网站：www.acediag.com 全国统一服务热线：021- 60496554 24小时手机服务: 13917250134（同微信）QQ：1715451510 Email：info@e-biochem.com